Presenilins: A novel link between intracellular calcium signaling and lysosomal function?
نویسندگان
چکیده
منابع مشابه
Presenilins: A novel link between intracellular calcium signaling and lysosomal function?
Mutations in presenilins (PS), transmembrane proteins encoding the catalytic subunit of γ-secretase, result in familial Alzheimer's disease (FAD). Several studies have identified lysosomal defects in cells lacking PS or expressing FAD-associated PS mutations, which have been previously attributed to a function for PS in lysosomal acidification. Now, in this issue, Coen et al. (2012. J. Cell Bio...
متن کاملRegulation of ryanodine receptor-mediated calcium signaling by presenilins.
Ca dyshomeostasis is a critical causative mechanism underlying the functional impairment of the central nervous system seen in ‘healthy’ aging , specifically in normal brain aging processes in the absence of disease-causing mutations or external causes. It is generally thought that such impairments result from the gradual accumulation of small changes at the molecular level, such as oxidative d...
متن کاملIntracellular calcium signaling.
In excitable cells, the major pathway for Ca2+ influx is via highly Ca2+-selective voltage-gated Ca2+ channels (VGCC). The original alphabetical nomenclature was replaced recently with standard numerical nomenclature: Cav1.1-1.4, Cav2.1-2.3, Cav3.1-3.3. In skeletal muscle cells, an additional voltagesensitive pathway is provided by dihydropyridine receptors (DHPR, Cav1.1) that do not pass signi...
متن کاملOptimal intracellular calcium signaling.
In many cell types, calcium is released from internal stores through calcium release channels upon external stimulation (e.g., pressure or receptor binding). These channels are clustered with a typical cluster size of about 20 channels, generating stochastic calcium puffs. We find that the clustering of the release channels in small clusters increases the sensitivity of the calcium response, al...
متن کاملMitochondrial transporters as novel targets for intracellular calcium signaling.
Ca(2+) signaling in mitochondria is important to tune mitochondrial function to a variety of extracellular stimuli. The main mechanism is Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. This results in increases in mitochondrial NADH/NAD ratios and ATP levels and increased substrate uptake by mitochondria. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2012
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.201206003